Senior Research Associate, Formulations

Who We Are:

ReCode Therapeutics is an integrated genetic medicines company developing targeted, disease-modifying medicines for patients with life-limiting respiratory diseases. Our treatments address the underlying genetic cause in underserved populations and have the potential to tremendously impact the quality and length of patients’ lives.

At ReCode, we bring a unique blend of rigor, creativity, and curiosity to our high-hurdle mission: harnessing our multi-platform approach to develop disease-modifying medicines. Our team is uniquely positioned to tackle this challenge, given our extensive experience in RNA delivery technologies, protein structure, tRNA biology, mRNA manufacturing, gene editing, and drug development.

Summary of Position:

ReCode is seeking a Senior Research Associate to work as part of a team to conduct laboratory experiments to support the development of robust scalable LNP-encapsulated nucleic acids formulations and manufacturing processes, including lab-scale process development, process scaleup, and in-process characterization. You will have the opportunity to work as an integral part of a talented, diverse team of scientists, and develop career in the exciting field of RNA therapeutics. The ideal candidate will be proactive, enthusiastic, and show a passion for LNP-RNA formulation and process development and should have strong communication and collaboration skills, along with a background in LNP formulation and process development.

Responsibilities:

• Executes studies to define formulation components, vehicle, and primary container.
• Operates common biopharmaceutical unit operations such as mixing, dialysis, tangential flow filtration, and sterile filtration.
• Performs in-process characterization such as pH, particle size, encapsulation efficiency measurement etc.
• Conducts troubleshooting and technical investigations as needed.
• Executes experiments to meet agreed upon deliverables and timelines.
• Maintains thorough and detailed electronic lab notebooks and documentation records.
• Supports and participates in R&D and project management meetings.
• Adheres to all laboratory safety requirements and procedures.
• Assists in maintaining general laboratory functionality and lab equipment, including ordering and receiving of lab supplies.

Qualifications:

• B.S. in Chemical Engineering, Chemistry, Bioengineering, Material Sciences, Pharmaceutical Sciences or related scientific discipline with typically 5+ years laboratory experience or M.S. in Chemical Engineering, Chemistry, Bioengineering, Material Sciences, Pharmaceutical Sciences or related scientific discipline with typically 3+ years laboratory experience (ideally in organic chemical synthesis, nanoparticles, formulation development, nucleic acids, drug delivery)
• Hands-on experience with HPLC, UPLC, LC-MS and various analytical techniques is a must. Extensive hands-on experience on the analysis and characterization of lipids is preferred.
• Attention to detail and excellent skills in Microsoft Office and data analysis software (e.g., Empower, ChemStation, Chromeleon, etc.) and other applications.
• Must be comfortable working in a fast-paced, cross-functional environment and collaborate effectively with other team members.
• Strong oral and written communication skills to support internal and external communications/presentations.

Physical Requirements and Work Environment:

• Regularly required to stand, bend, reach, and work at a laboratory bench for extended periods; occasionally required to lift and move materials or equipment up to 25 lbs.
• Regularly exposed to laboratory chemicals, biological materials, and equipment; required to wear personal protective equipment (PPE) and follow all safety protocols.
• Reasonable accommodations will be made to enable individuals with disabilities to perform the essential functions of this role.

Benefits Offered: 

• Company pays full premium for employee + family medical, dental, and vision insurance
• Company-sponsored 401(k) plan with employer contribution
• 15 days of company paid holidays, including a week off between Christmas and New Year
• FSA available, including a lifestyle spending account subsidized by company
• Employee stock option grant and annual performance bonus

ReCode Therapeutics (www.recodetx.com) offers a competitive compensation/benefits package with a friendly, collaborative culture that values employee engagement and ongoing career development.

The expected base salary is $110,000 - $130,000, based on experience.

ReCode Therapeutics is an Equal Opportunity Employer. ReCode Therapeutics does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity or expression, national origin, age, disability, veteran status, or any other characteristic protected by applicable law, and provides reasonable accommodations for qualified individuals with disabilities upon request. This job description is intended to describe the general nature of the role and is not an exhaustive list of duties, responsibilities, or qualifications; duties may change at ReCode’s discretion. Employment with ReCode is at-will.